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In order to study 5-nitro-2-furaldehyde derivatives having more effective antibacterial activity, four new N⁴-(5-nitro-2-furfurylidene)-N¹-substituted sulfanilamides-N¹-3,4-dimethyl-5-isoxazoyl-N⁴-5-nitro-2-furfurylidene sulfanilamide, N¹-4,6-dimethyl-2-pyrimidyl-N⁴-5- nitro-2-furfurylidene sulfanilamide, N¹-6-methoxy-3-pyridazinyl-N⁴-5-nitro-2-furaldehyde sulfanilamide, and N¹-2,6-dimethoxy-4-pyrimidyl-N⁴-5-nitro-2-furfurylidene sulfanilamide - were synthesized which were obtained by the condensation of 5-nitro-2-furaldehyde with sulfa drugs such as sulfisoxazole, sulfamethazine, sulfamethoxypyridazine, and sulfadimethoxine. All compounds were tested for antibacterial activity in vitro on the following micro-organisms : Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris. Each compound exhibited a fair bacteriostatic activity against each microorganism. Above all, sulfisoxazole derivatives showed higher activity than the others. Each compound was most active against Staphylococcus aureus, whereas least active against Proteus vulgaris.
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